The Covid-19 pandemic is and will continue to have pervasive impacts on health and society. What key research questions and priorities are necessary to mitigate the impacts on mental health, especially for those people who may disproportionately affected? Louise Arseneault reflects on some of the research priorities and questions for mental health and brain sciences identified by an interdisciplinary group of people from across the bio-psycho-social spectrum in mental health science, including people with lived experience of mental health problems.